A Critical Review of Xanthelasma Cryotherapy

Cryotherapy for xanthelasma appearance improvement, does it work?

When seeking professional options for the cosmetic improvement of the yellowish marks around your eyes, cryotherapy is a technique that may be mentioned. Often called “freezing,” this procedure involves the controlled application of extreme cold, typically liquid nitrogen, to destroy targeted tissue. However, when it comes to xanthelasma, its effectiveness is severely limited by significant risks and a high potential for undesirable outcomes.

The core issue is that xanthelasma plaques are always located on the thin, delicate skin of the eyelid, directly adjacent to the eye. Cryotherapy is an inherently imprecise procedure, making it a high-risk choice for this sensitive area. The potential for side effects, such as scarring and permanent skin discoloration, often outweighs any potential cosmetic benefit.

Xanthelasma cryotherapy cosmetic procedure

The Xanthelasma Cryotherapy Cosmetic Procedure: A Closer Look

The cryotherapy process involves applying liquid nitrogen to the xanthelasma plaque for a few seconds. This freezes the water inside the skin cells, causing them to rupture and die. In the days following the procedure, the area will typically blister, scab over, and then heal as new skin forms. The recovery period often takes one to two weeks.

However, the results are frequently disappointing. The freezing process is difficult to control with the precision needed for the eyelid. It often fails to penetrate deep enough to address the entire lipid deposit, meaning traces of the yellowish cholesterol can remain infused within the newly healing skin. This leads to a very high rate of reappearance, often within a short period, necessitating repeated procedures. The fundamental challenge, as detailed in scientific reviews on PubMed Central, is that many conventional treatments struggle with high recurrence rates.

Cryotherapy and xanthelasma cosmetic concerns

The Inherent Problems with Xanthelasma and Cryotherapy

The primary issues with using cryotherapy for xanthelasma stem from the uncontrollable nature of the deep-freezing process.

  • Collateral Damage to Healthy Skin: The freezing agent cannot perfectly isolate the xanthelasma plaque. It inevitably affects the surrounding healthy skin cells. This includes melanocytes, the cells responsible for skin pigment. Destroying these cells can lead to permanent hypo-pigmentation (white spots) or trigger an inflammatory response that results in hyper-pigmentation (dark spots), creating a new and often more noticeable cosmetic issue.
  • Risk of Scarring: The intense freeze/thaw cycle is a significant trauma to the skin. The body’s healing response can be unpredictable, leading to the formation of atrophic (indented) or hypertrophic (raised) scars.
  • Uncontrollable Frostbite: To have any effect on the deep lipid deposits of xanthelasma, the level of freezing required is essentially a controlled frostbite. The line between cosmetically effective and dangerously damaging is exceptionally thin, especially near the eye.

The American Academy of Dermatology notes that while cryosurgery is useful for many skin conditions, it requires great skill, and side effects are always a possibility. For the delicate eyelid, these risks are significantly amplified.

Xanthelasma cosmetic improvement cream

Evaluating All Xanthelasma Cosmetic Approaches

Numerous clinical techniques have been utilized for Xanthelasma Palpebrarum (XP), including cryosurgery, laser ablation, and surgical excision. While performed by professionals, many of these invasive methods share a common drawback: a high probability of the plaques reappearing. The underlying lipid deposits are persistent, and if not addressed correctly, they will often return.

Xanthelasma cryotherapy complications

This is why a dedicated, non-invasive cosmetic gel like Xanthel ® has become a leading choice worldwide. It allows you to improve the appearance of your xanthelasma without the risks, downtime, and high recurrence rates associated with cryotherapy. Our formulas are engineered to provide an excellent cosmetic result while being gentle on the surrounding skin.

Cryosurgery skin procedure considerations

Xanthel ® features selective engineered formulas. Through dedicated research, this single, potent cosmetic gel was developed to address the distinct appearance of xanthelasma plaques. It provides the dramatic aesthetic advantages of a professional procedure with the convenience and comfort of at-home application, helping you achieve the confidence you deserve without compromise.

xanthel xanthelasma cream

Cosmetic Gel

Xanthel ®


Easy to Use
Our gel is formulated for one simple application to help improve the cosmetic appearance of your xanthelasma or xanthoma areas. A gentle and effective cosmetic solution.

Professionally Formulated
Designed for a single cosmetic application, our formula is engineered to help you achieve and maintain long-lasting aesthetic improvement for your plaques.

Legal: This product is for cosmetic use only. This product is not intended to diagnose, treat, cure, or prevent any medical condition. Consult a healthcare professional regarding any skin condition.